Amyotrophic lateral sclerosis
Conditions
Interventions
Decoction group:On the basis of normal clinical treatment group, the patients were required to drink Wuzhi Maotao Hongzao decoction.
Sponsors
South China Hospital of Shenzhen University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Subsequent patients diagnosed with amyotrophic lateral sclerosis (ALS); (2) Male and female, age 18-70 years old; (3) Mild, moderate patients, with a certain swallowing function; (4) Provide blood glucose, blood routine, liver and kidney function, immune function (CD3,CD4,CD8, interleukin-6) test reports within one week before enrollment; (5) Voluntarily participate in this clinical trial, give informed consent and sign informed consent.
Exclusion criteria
Exclusion criteria: (1) Severe renal insufficiency: creatinine clearance 3 times the upper limit of normal, or other known liver diseases such as acute and chronic active hepatitis, cirrhosis, diabetes, etc; (3) During the screening period, patients with heart failure (Class III-IV patients according to NYHA classification) developed acute myocardial infarction or underwent interventional therapy within the last 6 months; (4) Complicated with malignant tumors, serious diseases of blood, digestion or other systems; (5) Allergic constitution.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ALSFRS-R;ADL-Barthel;ALSAQ-40;6MWT;Borg dyspnea score;the UK Medical Research Council;EDSS ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intestinal microbiome species;Intestinal microbial metabolites; | — |
Countries
China
Contacts
Public ContactNan Liu
South China Hospital of Shenzhen University
Outcome results
None listed