premature ovarian insufficiency
Conditions
Interventions
acupoint catgut embedding group:acupoint catgut-embeddingin
HRT group:Femoston
sham acupoint catgut embedding group:sham acupoint catgut-embedding
Sponsors
Shenzhen Bao'an Chinese Medicine Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: (1) Women aged 15 IU/l on two occasions>4 weeks apart; (4) 8=HRSD17=22; (5)50=SAS=69.
Exclusion criteria
Exclusion criteria: (1) Abnormal chromosomal analysis (which includes turner syndrome, detectable Y chromosomal material, fragile X syndrome); (2) Iatrogenic POI (which includes chemotherapy, radiotherapy and ovary removal surgery); (3) Autoimmune diseases (which includes Addison’s disease and autoimmune thyroid disease); (4) No HRT and acupuncture treatment for at least 3 months before study enrollment; (5) Hemostatic disorder; (6) Chronic illnesses (which includes liver disease, diabetes, hypertension and cardiovascular diseases); (7) unwillingness to sign the informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the modified Kupperman index;17-item Hamilton Rating Scale for Depression;self-rating anxiety scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Follicle-stimulating hormone;Estriol;Anti-Müllerian hormone ;Antral follicular count ;Serum BDNF;corticotropin releasing factor ;adrenocorticotropic hormone;cortisol; | — |
Countries
China
Contacts
Public ContactGuizhen Chen
Shenzhen Bao'an Chinese Medicine Hospital
Outcome results
None listed