Nausea and vomiting after general anesthesia
Conditions
Interventions
Opioid-free anesthesia group:opioid-free anesthesia regimen was used during the surgery
Fentanyl group:opioid anesthesia regimen was used intraoperatively
Sponsors
The First Affiliated Hospital of Fujian Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Patients undergoing thyroid surgery and were included; 2.The ASA classification is I to III; 3.18 <=Age<=65 years old; 4.BMI=30 kg/m2; 5.No psychiatric abnormalities; 6.No use of antiemetic drugs within 24 hours before surgery; 7.No serious endocrine, cardiovascular, respiratory diseases before surgery; 8.No history of smoking; 9.Volunteer to participate in the study and sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) a goiter causing tracheal compression or dyspnea; (2)hyperthyroidism or hypothyroidism; (3) obstructive sleep apnea syndrome; (4) left ventricular ejection fraction <40%,second-degree or greater atrioventricular block, sick sinus syndrome, or severe bradycardia [heart rate (HR) < 50 beats/min]; (5) serious liver or renal dysfunction (Child Pugh grade C or need for renal replacement therapy); (6)epilepsy or seizures; (7) chronic pain or preoperative use of sedatives and analgesics; (8) allergies to any medication in this study; (9) pregnancy or breastfeeding; (10) inability tocommunicate preoperatively.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative nausea and vomiting; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative hemodynamic indicators;General condition of the patient;Postoperative use of antiemetics;Postoperative use of analgesics;Postoperative pain score;Changes in postoperative cognitive function; | — |
Countries
China
Contacts
Public ContactYouguang Gao
The First Affiliated Hospital of Fujian Medical University
Outcome results
None listed