oral leukoplakia
Conditions
Interventions
Group A:orally take retinoid acid, 0.4-0.6mg/Kg/day, for 3 months
Group B:Topically applling ALA-Photodynamic Therapy
Group C:Topical laser pretreatment of hyperkeratotic lesions combined with ALA photodynamic therapy
Sponsors
West China Hospital of Stomatology, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18 and 75 years; 2. Clinically or pathologically diagnosed as oral leukoplakia(with or without epithelium dysplasia); 3. The results of basic physical examination are normal; 4. Those who participate in the study independently and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1.Allergy to light or porphyrins; 2.Histopathologic diagnosis of invasive carcinoma; 3.Those at high risk for local anesthesia; 4.Pregnant or lactating women; 5.Those with other severe mucous diseases; 6.Those with other severe systemic diseases that are not controlled by medication; 7.Those with history of psychiatric disorders, poor general conditions or cognitive impairment who can not to cooperate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| lesion size;White spot elimination rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Elimination time ;degree of roughness;recurrence rate; | — |
Countries
China
Contacts
Public ContactHongmei Zhou
West China College of Stomatology, Sichuan University
Outcome results
None listed