sepsis-induced gastrointestinal dysfunction
Conditions
Interventions
treatment group:Conventional Western medicine treatment + Wenchang Tongfu Decoction 10g(+warm water 50ml) nasogastric feeding q4h and 20g(+warm water 150ml) ml enema q6h for 3 days
control group:Conventional Western medicine treatment + placebo10g(+warm water 50ml) nasogastric feeding q6h and 10g(+warm water 150ml) ml enema q6h for 3 days
Sponsors
Hospital of Chengdu University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1) In accordance with the western medicine diagnostic criteria of sepsis-induced Gastrointestinal Dysfunction; (2)Traditional Chinese Medicine (TCM) syndrome differentiation identifies the pattern as "Yangxu of Pishen,Yuxue Fushi" (3) Estimated ICU length of stay = 72 hours; (4) Age 18-85 years (inclusive), gender not limited; (5) Sign informed consent form.
Exclusion criteria
Exclusion criteria: (1) Gastrointestinal dysfunction caused by gastrointestinal surgery; (2) Patients with contraindications to enteral nutrition and enema, or mechanical intestinal obstruction; (3) Individuals allergic to medications used in the protocol; (4) Pregnant or lactating women; (5) Engaged in other drug research at the time of enrollment; (6) Presence of other factors that may affect the examination or treatment efficacy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| diamine oxidase; | — |
Secondary
| Measure | Time frame |
|---|---|
| D-lactic acid;lymphocyte count;CD4+/CD8+ T cell ratio;total levels of IgG, IgM, and IgA ;28-day mortality rate;reflux volume;time to resolution of vomiting;time to resolution of bowel sounds;number of bowel movements per day; | — |
Countries
China
Contacts
Public ContactKaichen Zhang
Hospital of Chengdu University of Traditional Chinese Medicine
Outcome results
None listed