Anesthetic drug neurotoxicity
Conditions
Interventions
Lipoic acid group:600mg lipoic acid was administered before induction of anesthesia
control group:The same amount of saline is administered before induction of anesthesia
Sponsors
Xuzhou Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 60 years; 2. ASA grade I-III; 3. Patients with indications for hepatectomy surgery and operating time of not less than 2 hours; 4. Agreed to participate in this study and signed an informed consent form.
Exclusion criteria
Exclusion criteria: 1. People with contraindications to sevoflurane use; 2. Allergic to lipoic acid; 3. Patients with serious heart, lung, kidney and other vital organ diseases; 4. Patients with serious infectious diseases, endocrine system diseases and blood system diseases; 5. People with a history of smoking, alcohol and drug abuse; 6. Received radiation or antioxidant medication in the week before surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 8-hydroxy-2 deoxyguanosine; | — |
Secondary
| Measure | Time frame |
|---|---|
| sORP(static oxidation-reduction potential);cORP(capacity oxidation-reduction potential );UCH-L1;S100-ß;MoCA(Montreal cognitive assessment); | — |
Countries
China
Contacts
Public ContactZhou Meiyan
Xuzhou Central Hospital
Outcome results
None listed