postoperative delirium
Conditions
Interventions
control group:After admission to the laboratory, routine anesthesia monitoring, general anesthesia induced propofol 1.5mg/kg, sufentanil 0.3-0.6ug/kg, cis-atracurium besylate 0.15mg/kg, followed by in
After the end of the operation, a disposable electronic pump intravenous self-controlled analgesia (PCIA, sufentanil 0.03ug/kg/h + tropisetron 10 mg) was started with a total volume of 100 ml, and con
opioid-sparing group(K1 group):After admission, routine anesthesia monitoring, general anesthesia induced propofol 1.5mg/kg, sufentanil 0.3ug/kg, esketamine 0.25mg/kg, cis-atracurium besylate 0.15mg/k
After the end of the operation, a disposable electronic pump was started with intravenous self-controlled analgesia (PCIA, sufentanil 0.03 ug/kg/h + esketamine 0.015 mg/kg/h + tropisetron 10 mg) with
opioid-free group(K2 group):After entering the room, routine anesthesia monitoring was induced by general anesthesia with propofol 1.5 mg/kg, esketamine 0.5 mg/kg, cis-atracurium besylate 0.15 mg/kg,
Sponsors
Xuzhou Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1) Age 18-85 years old; 2) Patients who are expected to undergo elective non-cardiac surgery and the operation time is =4 hours; 3) ASA Grading I-III; 4) No communication barriers, clear consciousness; 5) BMI of 18.5-29.9 kg/m2; 6) voluntary use of postoperative intravenous analgesic devices; 7) In line with ethics, the patient voluntarily underwent the test and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1) Those who have contraindications or allergies to esketamine and other anesthetic drugs; 2) Identify/suspect abuse or long-term use of narcotic sedative analgesics; 3) Patients with severe hypertension and severe cardiovascular disease; 4) Any cerebrovascular accident within 3 months; 5) Patients with pulmonary hypertension, intracranial pressure or intraocular hypertension; 6) history of psychiatric illness, central nervous system injury; 7) Patients with severe liver and kidney insufficiency; 8) Have a history of antidepressant and other psychotropic drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Anti-inflammatory factor;Inflammatory factors;Blood-brain barrier injury biomarkers and neuronal apoptosis biomarkers;Perioperative hemodynamics;Postoperative pain score;Postoperative shiver;Cognitive Function; | — |
Countries
China
Contacts
Public ContactQi Yu
Xuzhou Central Hospital
Outcome results
None listed