poor ovary response
Conditions
Interventions
Treatment group:The subjects will be given Reco-18 with dose of 8 capsules/day in 1-5 days of the menstrual cycle, which will be used for two menstrual cycle. In the third Menstrual cycle, subjects wi
Control group:The subjects will be given placebo with dose of 8 capsules/day in 1-5 days of the menstrual cycle, which will be used for two menstrual cycles. In the third Menstrual cycle, subjects wil
Sponsors
Beijing Chao-Yang Hospital, Capital Medical University
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Age : 20 = Age = 40 years old; 2. Women in the first or second IVF/ICSI cycle; 3. BMI = 25Kg/m2; 4. Meeting with IVF/ICSI indications for assisted pregnancy; 5. Meeting with POSEIDON criteria (1:Age<35 years old, AFC= 5 or AMH= 1.2 ng/mL, and = 9 eggs taken in the previous cycle; 2: Age = 35, AFC = 5 or AMH = 1.2 ng/mL, with = 9 eggs retrieved in the previous cycle; 3: Age<35 years old, AFC<5 or AMH<1.2 ng/mL; 4: Age = 35, AFC<5 or AMH<1.2 ng/mL)
Exclusion criteria
Exclusion criteria: 1. Recurrent implantation failure (3 or more embryo transfer cycles failure in the past); 2. Moderate and severe endometriosis or adenomyosis; 3. Untreated hydrosalpinx; 4. Untreated uterine adhesions or submucosal fibroids; 5. The patient is currently not suitable for ART-assisted pregnancy or is associated with diseases that are not suitable for pregnancy; 6. Chromosome abnormalities (excluding polymorphisms) in both spouses; 7. Participated in clinical trials of other drugs within one month prior to enrollment; 8. There are other uncontrolled endocrine diseases that affect hormone secretion and metabolism (such as hyperthyroidism, hypothyroidism, adrenal diseases, obesity, etc.);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ongoing pregnancy rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of retrieved oocytes;High quality embryo rate;Biochemical pregnancy rate;Embryo implantation rate;Miscarriage rate; | — |
Countries
China
Contacts
Public ContactQun Lu
Beijing Chao-Yang Hospital, Capital Medical University
Outcome results
None listed