Transthyretin amyloid cardiomyopathy
Conditions
Interventions
Elderly patients with HFpEF:None
Sponsors
Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Outpatient, emergency and inpatient patients who were considered to have heart failure based on clinical symptoms, signs, and elevated levels of B-type natriuretic peptide, and underwent echocardiography examination. (2) Age =60 years. (3) Echocardiogram showing left ventricular ejection fraction =50% (with sinus rhythm) or =40% (with atrial fibrillation), interventricular septal thickness =12mm, left ventricular end-diastolic diameter <50mm (female) or <55mm (male).
Exclusion criteria
Exclusion criteria: (1) Definitive diagnosis of myocardial infarction. (2) Definitive diagnosis of primary amyloidosis or multiple myeloma. (3) Presents with segmental wall motion abnormality. (4) Presents with severe valvular disease (as evidenced by medical history or this current echocardiographic examination). (5) Considered to have pulmonary disease (such as pulmonary embolism or chronic obstructive pulmonary disease) resulting in related symptoms. (6) Left main artery or proximal left anterior descending artery stenosis, or = 2 major coronary arteries with significant stenosis (>70%). (7) Patients who have already been included in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Echocardiography;Vital signs;natriuretic peptide;Serum immunofixed electrophoresis;Urine immunofixation electrophoresis;Serum free light chain;99m Technetium-pyrophosphate scintigraphy;Electrocardiogram;TTR gene screening; | — |
Countries
China
Contacts
Public ContactShuyang Zhang
Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences
Outcome results
None listed