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Changes in optic nerve structure and function before and after intravitreal injection of anti VEGF drugs

Changes in optic nerve structure and function before and after intravitreal injection of anti VEGF drugs

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300077251
Enrollment
Unknown
Registered
2023-11-02
Start date
2023-11-02
Completion date
Unknown
Last updated
2023-11-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetic Macular Edema Retinal Vein Occlusion Wet Age-related Macular Degeneration Subchoroidal Neovascularization Of Macular Choroid

Interventions

Test group:Intravitreous injection of anti VEGF drugs

Sponsors

The Second Hospital of Dalian Medical University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients aged between 18 and 80 years old, regardless of gender. The patient is diagnosed with DME, AMD, BRVO, CNV; Patients who need to receive intravitreal injection of anti VEGF drugs (ranibizumab, alboxepril, or conbercept) into the affected eye. Injected intraocular pressure ranges from 10mmHg to 21mmHg. Patients who voluntarily sign informed consent forms.

Exclusion criteria

Exclusion criteria: patients with vitreous hemorrhage, Retinal detachment, retinal holes and other diseases that need further surgery. Patients who have or are currently suffering from optic neuropathy, such as glaucoma, optic neuritis, anterior ischemic optic neuropathy, optic atrophy, traumatic optic neuropathy, toxic optic neuropathy, Leber optic neuropathy, etc. Patients who require further panretinal laser photocoagulation treatment after injection. Patients who have received intravitreal injection of anti VEGF drugs or Aodi Shi in the past 3 months; Patients who have received retinal laser photocoagulation therapy, iridectomy laser therapy, and posterior cataract laser therapy within the past 3 months, and patients who have received retrobulbar/parabulbar injection of glucocorticoids within the past 1 month. Patients who have undergone Cataract surgery and glaucoma surgery within 3 months. Patients with severe systemic diseases, such as heart disease, hypertension, abnormal liver and kidney function, abnormal coagulation function, high sensitivity constitution, etc. Mental disorders caused by other causes (physical illness, psychoactive substances). Cognitive impairment caused by severe Alzheimer's disease, Huntington's disease, Hydrocephalus, and long-term use of antiepileptic drugs. Pregnant and lactating women. Patients who cannot cooperate with the examination and patients who cannot communicate normally.

Design outcomes

Primary

MeasureTime frame
best corrected visual acuity; visual field ;VEP;

Secondary

MeasureTime frame
retrobulbar vascular ultrasound;OCT;

Countries

China

Contacts

Public ContactLiu Fei

The Second Hospital of Dalian Medical University

drliufei@dmu.edu.cn+86 177 0987 2593

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026