pain and anxiety
Conditions
Interventions
Esketamine group(K group):A loading dose of 0.1mg/kg of esketamine was administered intravenously, followed by patient-controlled intravenous analgesia (PCIA, 0.015mg/kg/h of esketamine plus 150ml of
Control group(C group):One tablet of tramadol acetaminophen (tramadol 37.5mg+ acetaminophen 325mg) was given orally every 6 hours (1 tablet/time) for 3 days.
Sponsors
Xuzhou Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. The age ranged from 18 to 85 years 2. Emergency trauma admission patients 3. The pain score was =4 on admission 4. There was no communication disorder and clear consciousness 5. BMI was 18.5-29.9 kg / m2 6. Use of a patient-controlled intravenous analgesia device was voluntary 7. It was ethical, and patients volunteered to participate in the study and signed informed consent
Exclusion criteria
Exclusion criteria: 1. Contraindications or allergies to esketamine and other analgesics are present 2. Established or suspected abuse or long-term use of narcotic sedatives and analgesics 3. Severe hypertension, serious cardiovascular disease 4. Any traumatic brain injury or cerebrovascular accident occurred within 3 months 5. Pulmonary hypertension, intracranial pressure or intraocular pressure 6. History of mental illness, central nervous system injury 7. Severe hepatic and renal insufficiency 8. Patients with thoracic and abdominal important organ injuries 9. The pregnant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain score; | — |
Secondary
| Measure | Time frame |
|---|---|
| State of anxiety;Indicators of myocardial injury and renal injury;Vital signs(Oxygen saturation, respiratory rate, heart rate, blood pressure);Level of inflammatory response; | — |
Countries
China
Contacts
Public ContactQi Yu
Xuzhou Central Hospital
Outcome results
None listed