acute appendicitis
Conditions
Interventions
Control group:Antibiotics therapy
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Aged 18 years or older (no upper age limit); 2) Clinical suspicion of AUA and confirmed by CT scan: a. An appendiceal diameter larger than 6 mm and smaller than 15 mm with a thickened, contrast-enhanced wall along with periappendiceal edema and/or minor fluid collection, with or without appendicolith(s). b. The absence of the criteria of complicated acute appendicitis (presence of gangrene, perforation, abscess, or suspicion of tumor). 3) Signed informed consent.
Exclusion criteria
Exclusion criteria: 1) Complicated acute appendicitis in a CT scan: presence of gangrene, perforation, periappendicular abscess or suspicion of a tumor; 2) Concurrent acute abdominal conditions, diffuse peritonitis, hemodynamic instability, or sepsis; 3) Severe systemic illness, eg, malignancy requiring active treatment (eg, chemotherapy), a medical condition requiring immunosuppressant medication; 4) Allergy or contraindication to proposed antibiotic therapy; 5) Pregnancy or lactating; 6) Inability to co-operate and give informed consent; 7) Allergy to laxative, contrast media, or iodine; 8) Past history of inflammatory bowel disease (IBD) or intestinal tuberculosis; 9) Actively taking metformin; 10) Kidney insufficiency or serum creatinine value exceeding the upper reference limit; 11) Another infection currently treated with systemic antibiotics; 12) Long-term use of steroids or anticoagulant therapy; 13) Prior enrollment in the study or other investigational drug or vaccine while on study treatment;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Treatment success rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall complication rate;The length of hospital stay and the amount of sick leave;Postintervention pain scores (VAS score);Postintervention quality of life;Patient-reported resolution of symptoms;Overall treatment costs; | — |
Countries
China
Contacts
Public ContactXin Yang
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed