Gram-negative bacteria infection
Conditions
Interventions
Patients with multidrug-resistant gram-negative bacteria treated with polymyxin or ceftazidime-avibatam:None
Sponsors
The Third Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Pathogen culture results of carbapenem-resistant gram-negative bacterial infection; (2) A drug sensitivity test showing resistance to carbapenem antibiotics; (3) Sensitivity to polymyxin B, colistin sulfate, or ceftazidime-avibactam; (4) Duration of treatment > 72h.
Exclusion criteria
Exclusion criteria: (1) Patients who are allergic to therapeutic drugs; (2) non-intravenous or atomized administration; (3) non-hospitalized patients; (4) Patients for whom the available data are insufficient to judge the clinical outcome or renal toxicity; (5) Combined with malignant tumors or multiple organ failure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma concentration; | — |
Secondary
| Measure | Time frame |
|---|---|
| C-reactive protein;Procalcitonin;White blood cell; | — |
Countries
China
Contacts
Public ContactPei Qi
The Third Xiangya Hospital of Central South University
Outcome results
None listed