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Study on the influence of different sperm preparation methods on the ICSI outcomes of patients with high sperm DNA fragmentation rate: a randomized sibling oocyte study

Study on the influence of different sperm preparation methods on the ICSI outcomes of patients with high sperm DNA fragmentation rate

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300077206
Enrollment
Unknown
Registered
2023-11-01
Start date
2023-11-01
Completion date
Unknown
Last updated
2024-09-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

infertility

Interventions

microfluidic:Preparing sperm by microfluidic devices
gradient contrifugation:Preparing sperm by gradient contrifugation

Sponsors

the First Affiliated Hospital of Kunming Medical University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Autologous sperm and oocyte; 2. First cycle; 3. Sperm DFI > 30%; 4. The woman's age is less than 38 years old.

Exclusion criteria

Exclusion criteria: 1. Patients undergoing pre-implantation embryo genetic testing (PGT); 2. Excluding common male infertility factors such as karyotype abnormalities, AZF microdeletions, orchitis, epididymitis, varicocele, history of reproductive system surgery, history of mumps, sexually transmitted diseases such as syphilis and AIDS; 3. Testicular sperm or frozen-thawed sperm; 4. The number of Retrieved oocytes < 10.

Design outcomes

Primary

MeasureTime frame
High-quality embryo rate;blastocyst formation rate;—

Secondary

MeasureTime frame
sperm DNA fragmentation rate;sperm recovery rate;fertilization rate;PR after preparation;—

Countries

China

Contacts

Public ContactShuhua Zhao

the First Affiliated Hospital of Kunming Medical University

kmshh1982@126.com+86 138 8810 1931

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026