Heart-valve disease
Conditions
Interventions
Experimental group:Applied the mini-cardiopulmonary bypass technology
Control group:Applied the conventional cardiopulmonary bypass technology
Sponsors
Shanghai Geriatric Medicine Center
Eligibility
Sex/Gender
All
Age
70 Years to 100 Years
Inclusion criteria
Inclusion criteria: ? Consciously sign the informed consent form and follow the requirements of the protocol; ? Age is 70 years old, gender is unlimited; ? Based on the results and history of transthoracic and (or) transesophageal echocardiography, coronary angiography or surgical exploration, the diagnosis of valvular disease or valve disease with coronary heart disease is clear.
Exclusion criteria
Exclusion criteria: ? Unable to tolerate the operation; ? Acute myocardial infarction occurred within 14 days prior to enrollment; ? Mechanical circulatory supportive therapy is being used; ? Haematological diseases; ? History of stroke within 90 days before enrollment, or a history of cerebrovascular disease combined with uncorrected carotid artery stenosis (> 80%); ? Having abdominal aortic aneurysm or thoracic aortic aneurysm (> 5 cm in diameter) or having severe atherosclerosis; ? Uncontrolled infection; ? Severe chronic obstructive pulmonary disease or pulmonary embolism; ? Moderate and above hepatic and renal insufficiency; ? Pulmonary artery systolic pressure over 60 mmHg or pulmonary vascular resistance> 5 Woods Units, transpulmonary pressure 16 mmHg; ? Combined with mental illness, psychological problems or cognitive dysfunction, can not cooperate with the treatment; ? Having a malignant tumor; ? Participate in other investigational drug or device trials in the last three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of change in hemoglobin level before and after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| All-cause mortality at 7 days after surgery;Perioperative rate of cardiopulmonary bypass-related complications; | — |
Countries
China
Contacts
Public ContactYun Zhao
Shanghai Geriatric Medicine Center
Outcome results
None listed