Obstructive sleep apnea-hypopnea syndrome
Conditions
Interventions
Individualized dietary therapy group:Individualized nutritional therapy
Individualized diet and non-invasive ventilation treatment group:Individualized diet and non-invasive ventilation treatment
Non invasive ventilator treatment group:General diet and non-invasive ventilation treatment
Sponsors
Changzhou Third People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1) Men and women aged 18-70 (including 18 and 70) at the time of signing the informed consent form; 2) BMI = 28.0kg/m2; 3) Agree to have meals, take medication, wear a ventilator, and monitor relevant indicators on time according to the protocol requirements throughout the entire research process, and keep records; 4) Willing to sign a written informed consent form and comply with the research protocol.
Exclusion criteria
Exclusion criteria: 1) Gastrointestinal diseases with malabsorption; 2) Congestive heart failure classified as III or IV by the New York Heart Association (NYHA); 3) In the stage of active liver disease or with significant liver function damage, defined as alanine aminotransferase (ALT) = 2.5 times the upper limit of the normal range; 4) Having a history of unstable or rapidly progressing kidney disease, or having renal function impairment, defined as serum creatinine = 133umol/L (1.5mg/dl for males), or = 125umol/L (1.4mg/dl for females); 5) There is a risk of allergies or intolerance to the food and drugs used; 6) Pregnant women, or women who have the intention to conceive during the study, or women who have the possibility of giving birth and refuse to use efficient and medically recognized contraceptive methods during the study period, or women who are currently breastfeeding; 7) Having mental disorders, unwillingness to communicate with others, or language barriers that prevent them from fully understanding the research plan or cooperating with researchers; 8) Any type of malignant tumor (whether cured or not); 9) Have a history of drug abuse. 10) Patients who require surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body measurement indicators;Analysis of human body composition;Sleep breathing monitoring; | — |
Secondary
| Measure | Time frame |
|---|---|
| Biochemical indicators;Inflammatory indicators; | — |
Countries
China
Contacts
Public ContactZhang Fan
Changzhou Third People's Hospital
Outcome results
None listed