ischemic stroke
Conditions
Interventions
Intervention group: Lifestyle intervention (including diet and weight management, etc.) + medication treatment (25mg of benzbromarone QD, if urinary pH <6, add 0.5g of sodium bicarbonate tablets TID,
Control group:Lifestyle intervention only.
Sponsors
Tianjin Huanhu Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: ? Age of onset between 18 and 80 years old; ? Acute ischemic stroke confirmed by CT or MRI within 48 hours of onset; ? History of gout according to the 2015 ACR/EULAR classification criteria, with serum uric acid level = 420 umol/L; ? Patients or their legally authorized representatives are able and willing to sign informed consent forms.
Exclusion criteria
Exclusion criteria: ? Experienced a gout attack within 1 week before the onset of ischemic stroke or currently undergoing uric acid-lowering treatment; ? Suffering from severe medical conditions such as renal insufficiency (glomerular filtration rate = 30 mL/min*1.73m2), liver dysfunction (Child-Pugh class C), or kidney stones; ? Expected lifespan less than 6 months due to end-stage disease; ? Participation in any other interventional trials within the past 3 months; ? Not suitable for participation in this clinical study or unable to complete the study procedures due to other circumstances, such as mental disorders, cognitive or emotional impairments, or physical conditions that prevent compliance with the study protocol and follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| recurrent gout;self-care ability; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neurological deficit;C-reactive protein;neutrophil-lymphocyte ratio;body composition data;recurrent ischemic stroke;recurrent hemorrhagic stroke;vascular death ; all-cause death; | — |
Countries
China
Contacts
Public ContactMa Aiwen
Tianjin Huanhu Hospital
Outcome results
None listed