Diseases of urinary system
Conditions
Interventions
Esketamine group (Part 1: 25 cases/Part 2: 47 cases):Esketamine (0.25mg /kg), slowly intravenous propofol infusion after 30 seconds (1.5mg /kg, slowly completed within 30s-1min)
Sufentanil group (Part 1: 25 cases/Part 2: 47 cases):Sufen (0.1 µg/kg), slowly intravenous propofol infusion after 30 seconds (1.5 mg/kg, slowly administered within 30s to 1min)
Sponsors
Beijing Friendship Hospital, Capital Medical University
Eligibility
Sex/Gender
Male
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Body Mass index (BMI) 18-28 kg/m^2; 2. Patients undergoing transurethral electrotomy or transurethral ureteroscopy ureteral laser lithotripsy for bladder lesions under non-tracheal intubation intravenous general anesthesia; 3. Age >=60 years old; 4. Male; 5. ASA grade I-III; 6. The estimated operation time is less than 60 minutes; 7. Sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Allergic to planned medication; 2. Severe liver and kidney dysfunction, abnormal coagulation function; 3. History of irregular hypertension or malignant hypertension; 4. Patients with severe circulatory diseases; 5. Patients with acute respiratory infections and other severe respiratory diseases such as asthma; 6. Preoperative neurological disease, mental illness or previous cognitive impairment; 7. Patients with elevated intracranial and intraocular pressure; 8. The researchers believe that patients who are not suitable to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hypoxic incidence;Propofol ED50 ; | — |
Secondary
| Measure | Time frame |
|---|---|
| MAP HR;Respiration rate;Propofol dosage;Vasoactive drug dosage;Incidence of perioperative adverse reactions;SpO2; | — |
Countries
China
Contacts
Public ContactAn Lixin
Beijing Friendship Hospital, Capital Medical University
Outcome results
None listed