diabetes
Conditions
Interventions
Experimental group:Dexamethasone 8mg i.v.
Control group:Normal saline
Sponsors
Guangdong Provincial People’s Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 60 years; 2. Type 2 diabetics; 3. The operative time of thoracoscopic lung resections was about 1.5-4h with general anesthesia; 4. Written informed consent.
Exclusion criteria
Exclusion criteria: 1. Serious dysfunction of heart, liver, kidney and other important organs; 2. Have a history of serious mental illness (schizophrenia, epilepsy, Parkinson's disease, etc.); 3. ASA >= IV grade; 4. Preoperative fasting blood glucose > 10 mmol/L, diabetic ketoacidosis, hyperglycemia hyperosmolar state, severe hypoglycemia events in the past three months; 5. Allergic to hormone drugs or long-term use of hormone drugs; 6. Tumor patients who have undergone preoperative chemoradiotherapy; 7. Emergency operation; 8. Postoperative transfer to ICU was planned; 9. Enrolment in other clinical trials; 10.Patients who are not fit to wear CGM (severe coagulation dysfunction, wear site infection, MRI required during hospitalization). 11. Other reasons that are considered unsuitable for study participation by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative maximal glucose change; | — |
Secondary
| Measure | Time frame |
|---|---|
| The consistency of blood glucose monitoring (BGM) systems measuring glucose within capillary blood and blood glucose measured by continuous glucose monitoring (CGM) system;Measures of glycemic variability during intraoperative, the 12-hour, 24-hour and 48-hour postoperative;Time in range (3.9-10.0mmol/L) during POD1 and POD2;Time above range (glucose 10.1-13.9 mmol/L) during POD1 and POD2;Time above range (glucose >13.9 mmol/L) during POD1 and POD2;Preoperative hemoglobin A1c;Postoperative C-reactive protein (CRP) concentrations;Intraoperative insulin requirement;48h PONV;VISUAL analogue scale (VAS)-pain scores, highest score during 0-24 and 24-48 hours;The incidence of postoperative pulmonary complications;The 24-hour and 48-hour postoperative quality of QoR-15 score;Length of hospital stay; | — |
Countries
China
Contacts
Public ContactShu Haihua, Zhang Xiaoyi
Guangdong Provincial People's Hospital
Outcome results
None listed