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Effect of norepinephrine and phenylephrine on shivering and coagulation in patients undergoing cesarean section under spinal anesthesia

Effect of norepinephrine and phenylephrine on shivering and coagulation in patients undergoing cesarean section under intraspinal anesthesia

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300077164
Enrollment
Unknown
Registered
2023-11-01
Start date
2023-11-01
Completion date
Unknown
Last updated
2023-11-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spinal anaesthesia-induced Shivering and hypothermia during cesarean section

Interventions

Sponsors

Hefei Second People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1. Pregnant women aged between 18 and 40 years old; 2.ASA classification I-II; 3. Single term pregnancy; 4. Undergo spinal anesthesia to perform cesarean section, and undergo body temperature monitoring and collection of umbilical artery blood and maternal venous blood during the perioperative period; 5. Agree to participate in this study;

Exclusion criteria

Exclusion criteria: 1. Unable or refusing to sign the informed consent form; 2. Those who are allergic to norepinephrine or phenylephrine or are not suitable for use; 3. Those with known abnormal fetal development; 4. Those with mesenteric or peripheral vascular thrombosis; 5. Those who are accompanied by severe heart, brain, liver, and kidney diseases; 6. Those who are currently using monoamine oxidase inhibitors or tricyclic antidepressants; 7. Those who are also participating in other clinical research; 8. Those who have contraindications to spinal anesthesia; 9. Those who are unable to communicate and cooperate.

Design outcomes

Primary

MeasureTime frame
Incidence of shivering;

Secondary

MeasureTime frame
Plasma clotting factor VIII activity (FVIII:C);Fibrinogen;D-dimer ;Core body temperature;The severity of shivering;Umbilical artery blood pH value;

Countries

China

Contacts

Public ContactJin-feng Bao

Hefei Second People's Hospital

252295142@qq.com+86 156 5518 0780

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 7, 2026