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Effects of epidural dexamethasone versus intravenous dexamethasone on post-cesarean analgesia --- a single-center, randomized, double-blind, placebo-controlled study

The effects of epidural dexamethasone and intravenous dexamethasone on postoperative patient-controlled epidural analgesia after cesarean section: a single center, randomized, double-blind, placebo-controlled study

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300077158
Enrollment
Unknown
Registered
2023-11-01
Start date
2023-11-01
Completion date
Unknown
Last updated
2023-11-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

post-cesarean analgesia

Interventions

Group A :epidural dexamethasone group:intravenous injection of 4ml 0.9% NaCl, epidural injection of 4ml (4mg) dexamethasone
Group B : intravenous dexamethasone group:intravenous injection of 4ml (4mg) dexamethasone, epidural injection of 4ml 0.9% NaCl
Group C :0.9%NaCl control group :intravenous injection of 4ml 0.9%NaCl, epidural injection of 4ml 0.9%NaCl

Sponsors

Northwest Women's and Children's Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1. ASA level 1-2; 2. Age = 18 years old; 3. Body mass index between 18 and 30; 4. Gestational week = 37 weeks; 5. Plan to electively perform lower uterine segment cesarean section under subarachnoid-epidural anesthesia; 6. Voluntarily participate in the research and sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Those who are allergic to the study drug; 2. Uncontrolled hypertension; 3. There are contraindications for subarachnoid-epidural anesthesia; 4. History of alcohol or drug abuse; 5. Glucocorticoids have been used within 14 days; 6. Take prescription painkillers within 4 weeks; 7. Take over-the-counter pain relievers within 48 hours; 8.uncontrolled diabetes.

Design outcomes

Primary

MeasureTime frame
Local anesthetic medication and morphine consumption within 48 hours after surgery;

Secondary

MeasureTime frame
NRS Pain Scale at rest and NRS Pain Scale during movement in 48 hours after surgery;sensory nerve block time by mechanical stimulation;postoperative recovery time of motor function;Incidence of postoperative chills, nausea, vomiting, headache, itching.;Breastfeeding rate within 48 hours;General Comfort Questionnaire at 48 hours after surgery;

Countries

China

Contacts

Public ContactKaidi Cui

Northwest Women's and Children's Hospital

843095204@qq.com+86 186 8185 6170

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026