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Comparative study on the effects of norepinephrine and phenylephrine on fetal cerebral perfusion in preventing spinal anesthesia-induced hypotension during elective caesarean section

Comparative study on the effects of norepinephrine and phenylephrine on fetal cerebral perfusion in preventing spinal anesthesia-induced hypotension during elective caesarean section

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300077137
Enrollment
Unknown
Registered
2023-10-31
Start date
2023-11-01
Completion date
Unknown
Last updated
2023-11-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

spinal anaesthesia-induced hypotension during cesarean section

Interventions

Sponsors

Women's Hospital School of Medicine Zhejiang University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Women aged 18-40 with singleton pregnancy scheduled for elective cesarean section

Exclusion criteria

Exclusion criteria: Inability or refusal to give informed consent, contraindications to the use of phenylephrine or norepinephrine, allergy to ropivacaine, known fetal abnormality, obesity (body mass index >35 kg/m2), hypertension, preeclampsia , cardiovascular disease, rupture of fetal membranes, patients with contraindications to neuraxial anesthesia, and patients participating in other clinical studies

Design outcomes

Primary

MeasureTime frame
Fetal middle cerebral artery blood flow;Fetal umbilical artery blood flow;

Secondary

MeasureTime frame
Umbilical cord blood gas analysi;Apgar 1min and 5min scores;Changes in maternal blood pressure and heart rate during perioperative period;Liquid input and outpu;block plane;Frequency of remedial treatment for hypotension;Total operation time, total hospitalization time, spinal anesthesia drug injection-fetal delivery time, uterine incision-fetal delivery time;Fetal weight;

Countries

China

Contacts

Public ContactXiaowei Qian

Women's Hospital School of Medicine Zhejiang University

qianxw@zju.edu.cn+86 157 0015 7161

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026