bowel preparation
Conditions
Interventions
Multiple laxative group:Patients are given additional Macrogol 4000 powder 1 packet bid for 3 days before the conventional bowel cleansing regimen (taking 3 liters of polyethylene glycol solution and
Conventional laxative group:Patients are asked to take 3 liters of polyethylene glycol solution and Simethicone 5 hours before colonoscopy
Sponsors
The First Affiliated Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Age between 18 and 75 years old; (2) Meeting =2 of the following 6 criteria according to Rome IV criteria: experiencing difficulties during evacuations; passing dry or hard stools (Bristol type 1-2); feeling incomplete evacuation; experiencing a sensation of anorectal blockage; requiring manual assistance in evacuations; having spontaneous evacuations <3 times per week. Additionally, there is a rare occurrence of dilute feces without the use of laxatives. Chronic status is defined as symptoms first appearing at least 6 months prior to diagnosis and persisting within the last 3 months
Exclusion criteria
Exclusion criteria: (1) Patients with a history of intestinal obstruction, electrolyte disturbance, inflammatory bowel disease, or gastrointestinal tumors; (2) Patients with a previous history of gastrointestinal surgery; (3) Patients with serious coexisting diseases about heart, liver or kidney; (4) Patients that can not tolerant polyethylene glycol due to underlying diseases; (5) Pregnant or breastfeeding females; (6) Patients with a medication history of other gastrointestinal motility drugs, laxatives or anti-laxatives in the past 2 weeks; (7) Patients that allergic to polyethylene glycol; (8) Patients who are unable to provide informed consent or who are deemed unfit by the researcher to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bowel cleanliness (Boston Bowel Preparedness Rating Scale); | — |
Secondary
| Measure | Time frame |
|---|---|
| Completion rate of bowel preparation ;Adenoma detection ratio;Polyps detection ratio;Cecal intubation ratio;Defecation situation;Self-rating satisfaction degree ;Willingness to repeat bowel preparation;The incidence and severity of adverse events; | — |
Countries
China
Contacts
Public ContactChengfu Xu
The First Affiliated Hospital, Zhejiang University School of Medicine
Outcome results
None listed