Brain function after pediatric surgery
Conditions
Interventions
Propofol group:Anesthesia was induced by intravenous injection of propofol 2-4mg/Kg, and the depth of anesthesia was maintained by continuous intravenous infusion of propofol 2-8mg/Kg/h after the pati
Sevoflurane group:Anesthesia was induced by inhalation of 6%-8% sevoflurane, and the depth of anesthesia was maintained by inhalation of 2%-4% sevoflurane after the patient lost consciousness.
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 3 Years
Inclusion criteria
Inclusion criteria: 1) Age from 1 month to 3 years; 2) patients undergoing elective VPS; 3) an external drainage device or a ventriculoperitoneal shunt device has been placed.
Exclusion criteria
Exclusion criteria: 1) refuse to participate in the study; 2) intracranial tumors; 3) genetic diseases; 4) history of intracranial infection within the past month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proteomic changes in CSF 3 h after the end of surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of delirium during the recovery period;Levels of inflammatory factors in peripheral blood and cerebrospinal fluid;Proteomic changes in cerebrospinal fluid; | — |
Countries
China
Contacts
Public ContactDongliang Mu
Peking University First Hospital
Outcome results
None listed