Sarcopenia
Conditions
Interventions
Sponsors
Huadong Hospital affiliated to Fudan University
Eligibility
Sex/Gender
All
Age
65 Years to 110 Years
Inclusion criteria
Inclusion criteria: 1) Elderly surgical patients aged 65 years and older, undergoing general anesthesia with endotracheal intubation 2) The estimated surgery time is more than 1 hour.
Exclusion criteria
Exclusion criteria: 1) Participants who have been engaged in endurance strength training for six months or more before the start of this project. 2) Individuals taking medications that may affect the study, including aminoglycoside antibiotics, magnesium salts, lithium salts, anti-arrhythmic drugs (including beta-blockers, calcium channel blockers, lidocaine, procainamide, and quinidine), antiepileptic drugs, anti-tumor drugs, immunosuppressive drugs, hormones, and weight loss medications. 3) Individuals with limited mobility or severe cognitive impairments that could impact the effectiveness of patient observations. 4) Currently participating in other nutritional and exercise intervention programs. 5) Patients with severe cardiovascular, pulmonary, hepatic, renal, or neurological diseases, or infectious diseases. 6) Patients with severe disturbances in internal homeostasis, including acid-base imbalances, electrolyte disturbances, and hypoalbuminemia. 7) Neuromuscular disorders (such as myasthenia gravis, burns, upper/lower motor neuron injuries, and demyelinating neuropathies). 8) Patients with limited daily activity (as assessed by the Barthel Index) and comorbid joint diseases, fractures, or post-joint replacement surgery. 9) Those who cannot provide informed consent or have not signed an informed consent form. 10) Participants experiencing severe perioperative complications will be excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recovery Time = the elapsed time from 25% to 90% recovery of T1; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative pulmonary complications;Onset time(min) which is defined as the time from the intravenous injection of cisatracurium until disappearance of T1 of the train-of-four.;The time between 25% and 75% recovery of the control T1 value (recovery index, RI);The time between administration of NMBD and a TOF ratio of 0.9 (total recovery time, TRT); | — |
Countries
China
Contacts
Public ContactXixue Zhang
Huadong Hospital affiliated to Fudan University
Outcome results
None listed