Optimization of blood transfusion strategies for ICU patients with acute kidney injury undergoing continuous renal replacement therapy

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300077076

Enrollment

Unknown

Registered

2023-10-27

Start date

2023-09-15

Completion date

Unknown

Last updated

2023-10-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute kidney injury

Interventions

CRRT with a self-circulation procedure:CRRT using a self-circulation procedure during blood transfusion

CRRT without a self-circulation procedure:CRRT without a self-circulation procedure during blood transfusion

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: ? =18 years old. ? AKI patients hospitalized in the ICU who meet the stage 3 according to KDIGO guideline require CRRT treatment. ? There is a high risk of bleeding in clinical condition, such as post-major operations involving cardiothoracic, abdominal, spinal, and cranial surgeries, coagulopathy induced by trauma, sepsis, and active bleeding manifested as prothrombin time (PT), activated partial thromboplastin time (APTT) greater than 1.5 times normal or PT>18 seconds, APTT>60 seconds), and thrombocytopenia (<50 × 10^9/L), or combined use of anticoagulant, antiplatelet, thrombolytic drugs, etc., requiring blood transfusion treatment. ? Volunteer to participate in this study and sign an informed consent form. If the subject is unable to read and sign the informed consent form due to reasons such as lack of behavioral ability, their guardian is required to represent the informed process and sign the informed consent form. If the subject lacks the ability to read an informed consent form (such as an illiterate subject), a witness is required to witness the informed process and sign the informed consent form.

Exclusion criteria

Exclusion criteria: ? The CRRT treatment time is shorter than 24 hours. ? During the blood transfusion process, blood transfusion treatment is stopped due to side effects such as allergic reactions.

Design outcomes

Primary

Measure	Time frame
Filter survival;ICU survival;	—

Secondary

Measure	Time frame
CRRT supporting time;Changes in transmembrane pressure before and after blood transfusion;	—

Countries

China

Contacts

Public ContactJianping Gao

Sir Run Run Shaw Hospital, Zhejiang University School of Medicine

gaojp@zju.edu.cn+86 137 7740 0742

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026