head and neck squamous cell carcinoma
Conditions
Interventions
DWI guided DP-RT group (DWI group):The target volume GTV-DWI is defined as the area <ADC mean within the GTV. Radiation dose to GTV-DWI is escalated to 77Gy, and the fractional dose is escalated to 2.
Anatomic imaging group (control group):The standard radiotherapy dose of 70.0Gy was given to the target volume PGTV, with a fractional dose of 2.0Gy/F.
Sponsors
Hu'nan Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Locally advanced squamous cell carcinoma of the head and neck (oral, oropharyngeal, hypopharyngeal, laryngeal) confirmed by pathology or histology, except nasopharyngeal; age between 18 and 75 years; normal function of major organs, that is, blood routine and biochemical tests meet standards; a Karnofsky performance status score of at least 70; have no history of previous RT; no severe organ dysfunction ; the patient and their family have informed consent.
Exclusion criteria
Exclusion criteria: A history of previous RT, secondary malignancy, surgery, evidence of distant metastasis, presence of uncontrolled life-threatening illness, or pregnancy and lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| disease-free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| local recurrence-free survival;regional recurrence-free survival;locoregional recurrence-free survival;distant metastasis-free survival;overall survival; | — |
Countries
China
Contacts
Public ContactLiu Feng
Hu'nan Cancer Hospital
Outcome results
None listed