Dry eyes
Conditions
Interventions
0.01% concentration atropine group:Use 0.01% concentration atropine drops for both eyes nightly, one drop once a day
0.02% concentration atropine group:Use 0.02% concentration atropine drops for both eyes nightly, one drop once a day
Blank control group:Do not use any eye drops
Sponsors
The Second Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
6 Years to 10 Years
Inclusion criteria
Inclusion criteria: 1) Sign the informed consent form and be willing to follow up according to the prescribed time; 2) Age 6~10 years old, gender and race are not limited; 3) Normal near vision, distance vision < 1.0, distance vision can be corrected with concave lens (corrected visual acuity is = 1.0); 4) -0.5D= diopter =-6.00D, astigmatism=0.75DC; 5) Can adhere to medication for 12 months; 6) Only wear monofocal glasses to control myopia.
Exclusion criteria
Exclusion criteria: 1) History of systemic diseases related to ocular surface diseases, such as rheumatoid arthritis, gout and other rheumatological immunology diseases, thyroid diseases, diabetes mellitus; 2) Eyelid and skin inflammation, such as anterior blepharitis, atopic dermatitis, seborrheic dermatitis, rosacea, etc.; 3) Eyelid and conjunctival scarring lesions, such as trachoma, pemphigoid, chemical injury, thermal burn, radiation injury, etc.; 4) Ocular drug history: drugs that affect tear secretion and tear film stability, such as artificial tears, corticosteroid drugs, non-steroidal anti-inflammatory drugs, etc.; 5) History of previous ophthalmic surgery, eye trauma, and eye burns.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tear River height;Tear film breakup time;Degree of meibomian gland deletion and glandular morphological changes;OSDI questionnaire; | — |
Secondary
| Measure | Time frame |
|---|---|
| Lipid layer thickness grading;Conjunctival congestion score;Corneal fluorescence staining score; | — |
Countries
China
Contacts
Public ContactJing Wang
The Second Affiliated Hospital of Anhui Medical University
Outcome results
None listed