Parkinson
Conditions
Interventions
Trial group: Zhichan granules, 1 packet each time, twice a day
control groups:Zhichan Granules Analog, 1 packet each time, 2 times daily.
Sponsors
Affiliated Traditional Chinese Medicine Hospital of Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Those who meet the diagnostic criteria for Parkinson's disease; (2) Those aged 40 to 70 years; (3) Those whose condition is below grade 3 (including grade 3) according to the modified Hoehn-Yahr grading method; (4) Those who meet the diagnostic criteria for liver and kidney insufficiency in Chinese medicine; (5) Those with TCM evidence score =10; (6) Those with Parkinson's Disease Non-Motor Symptom Scale score NMSS >40; (7) Those who signed the informed consent.
Exclusion criteria
Exclusion criteria: (1) Those who had undergone surgery such as deep electrical stimulation in the six months prior to the trial; (2) Those with severe hypertension (blood pressure >180/120) with unsatisfactory control; (3) Psychiatric disorders, epilepsy, pregnant and lactating women; (4) Those who have combined severe cerebrovascular disease and have limb dysfunction caused by cerebrovascular disease; (5) Those with severe heart failure, renal failure, abnormal liver function, bone and joint diseases, etc., which affect the evaluation of the efficacy of this disease; (6) Alcoholism, drug addiction or severe intellectual impairment (including severe dementia), those who cannot take medication on time and those who cooperate with the examination; (7) Participants in other clinical trials within the last 2 months; (8) Patients with Parkinson's syndrome and Parkinson's superimposed sign; (9) Allergic and allergic to the known ingredients of the test drug and the control drug. (10) Severe depression HAMD-17 >24 and Insomnia Severity Index Scale (ISI) >21.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MDS-UPDRS; | — |
Secondary
| Measure | Time frame |
|---|---|
| NMSS;NMS Quest;PDQ-39;Chinese Medicine Symptom Score; | — |
Countries
China
Contacts
Public ContactLi Wentao
Affiliated Traditional Chinese Medicine Hospital of Shanghai University of Traditional Chinese Medicine
Outcome results
None listed