Mechanical Ventilation
Conditions
Interventions
mesh to jet group:using mesh nebulizer in the first stage and using jet nebulizer in the second stage
jet to mesh group:using jet nebulizer in the first stage and using mesh nebulizer in the second stage
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Over 18 years of age. (2) Invasive mechanical ventilation patients who received aerosol inhalation therapy and esophageal pressure monitoring.
Exclusion criteria
Exclusion criteria: (1) esophageal obstruction, esophageal perforation, severe esophageal variceal bleeding, upper gastrointestinal surgery, etc.; (2) thoracic malformation, diaphragmatic hernia, placement of chest tube; (3) severe heart, liver, kidney and other organ failure, hemodynamic instability; (4) end stage of pregnancy and tumor; (5) coagulation dysfunction (INR > 1.5s, APTT > 44s). (6) central or peripheral nervous system diseases or neuromuscular diseases; (7) palliative treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PTPes/min;PTPes;AI; | — |
Secondary
| Measure | Time frame |
|---|---|
| Respiratory mechanics indicators;Esophageal pressure related indicators; | — |
Countries
China
Contacts
Public ContactYuyan Zhou
West China Hospital, Sichuan University
Outcome results
None listed