Thoracic Surgery
Conditions
Interventions
Esketamine Group:after the anesthesia induction, 2mg/kg esketamine was infused in 15 minutes
Control Group:equal volume of normal saline was infused in 15minutes
Sponsors
Department of Anesthesiology in The Second Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Patients aged 18-70 years; 2. ASA: I-III; 3. Patients undergoing thoracic surgery; 4. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1.Patients who do not agree; 2. Patients who are allergic to esketamine; 3. Patients with a history of cardiac macrovascular disease such as atherosclerosis and hypertension; 4. Patients with neurological disease and increased intracranial pressure; 5. Patients with untreated or under-treated hyperthyroidism; 6. Patients who have or have had a history of severe mental disorders; 7. Patients with glaucoma; 8. Patients with preoperative chest radiographs suggesting pulmonary infection or other significant organ disease; 9. Patients with a history of drug abuse, especially morphine abuse or long-term glucocorticoid use; 10. Patients with increased white blood cell count, elevated neutrophil ratio, or elevated calcitoninogen above the upper limit of normal on preoperative examination; 11. Patients with a change in surgical procedure or bleeding volume greater than 1000 ml or surgical time longer than 6 hours; 12. Patients who participated in other clinical trials within 3 months prior to study enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma Bone Morphogenetic Protein-4;WBC count;Neutrophil count;Lymphocyte count;Monocyte count;Intraoperative blood pressure;Noggin;IL-1ß;TNF-a;IL-10; | — |
Secondary
| Measure | Time frame |
|---|---|
| visual analogue scale,VAS; | — |
Countries
China
Contacts
Public ContactLin Yang
The Second Xiangya Hospital of Central South University
Outcome results
None listed