Parkinson's disease
Conditions
Interventions
Case group:NA
Control group:NA
Healthy control group:NA
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
45 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) The 100 patients with Parkinson's disease (PD) who met the diagnostic criteria and exclusion criteria were 100 patients aged 45-80 in the neurology ward/outpatient department of the First Affiliated Hospital of Chongqing Medical University; (2) 100 AD patients aged 55-80 years were collected as a control group in outpatient clinics; (3) 100 healthy people were collected by recruitment, who did not suffer from neurological diseases but matched with the case group in gender, age, and past medical history. The diagnosis of patients with Parkinson's disease is based on the British Parkinson's Society Brain Bank Clinical Diagnostic Criteria. AD is diagnosed using the International Diagnostic Standards for Senile Dementia adopted by the Tenth Revision of 1992 (ICD-10).
Exclusion criteria
Exclusion criteria: (1) Patients suffering from other central nervous system diseases, including cerebrovascular diseases, intracranial infections, other central nervous system autoimmune diseases, demyelinating diseases, trauma, tumors, toxic diseases and metabolic diseases; (2) Patients with confounding factors that affect the immune system, such as depression, chronic inflammatory diseases, coagulation abnormalities, history of malignant tumors, patients taking anticoagulant drugs and patients taking nonsteroidal anti-inflammatory drugs one week before enrollment; (3) Consciousness impairment, severe hearing impairment, severe cognitive dysfunction, dementia, etc. who cannot complete the relevant scale assessment; (4) Those who refuse to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| DEGs;GO,KEGG;WGCNA;score of MDS-UPDRS; | — |
Secondary
| Measure | Time frame |
|---|---|
| score of the MMSE;score of RBD-SQ;score of SCOPA-AUT;score of PDSS; | — |
Countries
China
Contacts
Public ContactOumei Cheng
The first affilaited hospital of chongqing medical university
Outcome results
None listed