Restless legs syndrome,RLS
Conditions
Interventions
experimental group:chemical neurolysis of lumbar sympathetic nerve block (absolute alcohol injection/chemical neurolysis)
Sponsors
The First Affiliated Hospital of China Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Understand and voluntarily endorse informed consent; 2. Male or female and 18 years of age or older; 3. Patients who are diagnosed as RLS for the first time according to the International Restless Legs Syndrome Study Group diagnostic criteria for idiopathic RLS and have not used any drugs to treat RLS. 4. Patients who have an International Restless Legs Rating Scale (IRLS) score at baseline greater than 10 5. Patients who have suffered symptoms at least 3 times per week. 6. Patients who can be able to follow the drug dose and the follow-up plan; 7. Patients who can objectively describe the symptoms, can take the initiative to cooperate, without any mental illness.
Exclusion criteria
Exclusion criteria: Subjects complying with any of the following exclusion criteria are not eligible to participate in this study: 1. Patients who have any objections to this trial; 2. Serious organ damage, such as CHF (congestive heart-failure), patients with clinical symptoms of coronary artery disease and arrhythmia uncontrollable by existing medicines, etc.; 3. MRI examination showed that patients were not suitable for sympathetic nerve block 4.Patients with allergic diseases, allergic constitution, drug allergic history (gabapentin, pregabalin, oxycodone-acetaminophen, local anesthetics, absolute alcohol;); 5.Severe systemic infection, Coagulation dysfunction; 6.Patients with psychiatric disease affecting assessments; 7.Patients with malignant tumor or with a history of malignant tumor. 8. Patients unable to follow the follow-up plan; 9. Patients in other clinical research at the same time; 10. The patients that researchers do not consider fit for the trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| IRLS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pittsburgh Sleep Quality Index,PSQI;Athens Insomnia Scale,AIS;Visual Analogue Scale / Score,VAS;Clinical Global Impressions-S (CGI) scale;Drug consumption; | — |
Countries
China
Contacts
Public ContactDaosong Dong
The First Affiliated Hospital of China Medical University
Outcome results
None listed