Knee degenerative osteoarthrosis
Conditions
Interventions
Control group:Knee joint health education: Only use quadriceps isometric contraction exercise (three times a week, 30 minutes each time).
EA 0.5ma:Lower limb acupoint electroacupuncture 0.5ma, continuous wave, 2Hz. Acupoint selection: SP10, EX-LE3
ST32, EX-LE2
ST34,ST33. 3 times a week, 30 minutes each time.
EA 1ma:Lower limb acupoint electroacupuncture 1ma, continuous wave, 2Hz. Acupoint selection: SP10, EX-LE3
EA 1.5ma:Lower limb acupoint electroacupuncture 1.5ma, continuous wave, 2Hz. Acupoint selection: SP10, EX-LE3
Sponsors
The First Affiliated Hospital of Sun Yat sen University
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Conforming to the diagnostic criteria for degenerative joint disease: A. Western medicine diagnostic criteria (referring to the diagnostic criteria for knee osteoarthritis formulated by the American Society of Rheumatology in 2001): ? Age = 50 years old; ? Morning stiffness<30 minutes; ? Knee examination indicates bone hypertrophy; ? Bone sounds during joint activity; ? Bone tenderness; ? Radiological examination shows osteophyte formation; ? No significant synovial membrane temperature increase. Patients with 3 of the above 7 items are diagnosed with knee osteoarthritis. B. Diagnostic standards for traditional Chinese medicine (in accordance with the "Diagnostic Efficacy Standards for Traditional Chinese Medicine Diseases" issued by the National Administration of Traditional Chinese Medicine and the "Guiding Principles for Clinical Research of New Chinese Medicine Drugs" issued by the Ministry of Health) At the beginning, it is common to see dull pain in the knee joint. During activities, the joint cannot smoothly complete the flexion and extension movements, and the completion of the lateral movement is also not good. After rest or mild activities, the pain can be slightly reduced. When the temperature drops, it will recur and become difficult to recover over time; ? Local swelling of the knee joint is not difficult to detect. During movement, bone friction sounds or obvious bone friction sensation can be heard between the joints, and in severe cases, obvious joint deformities can be seen; ? The onset of the disease is slow, and it is more common in middle-aged and elderly people; ? Osteoporosis exists, and X-ray films can show narrowing of joint gaps, as well as bone hyperplasia in subchondral bones, and the formation of osteophytes can be seen; ? No abnormalities were found in the detection of erythrocyte sedimentation rate and anti "O", and no abnormal rheumatoid factors or mucins were detected. (2) Patients who voluntarily participated in this randomized controlled trial and signed informed consent forms
Exclusion criteria
Exclusion criteria: (1) Patients with central and peripheral nerve injuries and affected knee joints. (2) BMI index = 28 (3) Primary muscle diseases such as mitochondrial myopathy and periodic paralysis (4) Severe renal or parathyroid dysfunction (5) Individuals with mental disorders who cannot cooperate with treatment or examination (6) Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| WOMAC rating;TNF-a, TRPV1, CaMKII, Nrf2, CD11C, and CD206 contents in knee joint synovial fluid; | — |
Secondary
| Measure | Time frame |
|---|---|
| The ROM of knee; | — |
Countries
China
Contacts
Public ContactZhou Xin
The First Affiliated Hospital of Sun Yat sen University
Outcome results
None listed