Cognitive impairment
Conditions
Interventions
Saline group:None
Esketamine group :None
Sponsors
Shanghai Sixth People’s Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The clinical data of 50 patients with sepsis-related cognitive impairment who were Shanghai Sixth People's Hospital from March 2018 to April 2022 were analyzed retrospectively. All patients met the diagnostic criteria for sepsis in the third edition of the international consensus definition of sepsis and septic shock (abbreviated as"Sepsis 3.0") : life-threatening organ dysfunction resulting from an out-of-control response to infection (rapid increase in SOFA score =2) ; Patients with sepsis-related cognitive impairment were sedated with ketamine (n = 25) and patients with sepsis-related cognitive impairment were sedated with saline (n = 25) . In the observation group, there were 13 males and 12 females, with an age of (70 ± 5.5) years and a body mass index (BMI) of (22 ± 1.5) kg. M-2, mean years of education (7.3 ± 4.0) A, mini-mental state examination (MMSE) score at admission (27.5 ± 1.2) . In the control group, there were 10 males and 15 females, with an age of (72 ± 5.7) years and a body mass index (BMI) of (21.5 ± 1.7) kg. M-2, mean years of education (6.9 ± 3.5) A, mini-mental state examination (MMSE) score at admission (27.7 ± 1.2) points. There was no significant difference between the two groups in sex, age, BMI, years of education and preoperative MMSE (P > 0.05) .
Exclusion criteria
Exclusion criteria: ?Patients with central nervous system disease, mental disorders or psychological disorders before operation; ? Patients with adverse effects of long-term medication on mental system function;? Patients with severe abnormality of liver and kidney function;? Patients with secondary metabolic factors such as hyperthyroidism;?Patients with severe hypertension and cerebrovascular disease;? Patients with visual and hearing impairment who can not communicate normally.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MMSE; | — |
Secondary
| Measure | Time frame |
|---|---|
| PCT;Inflammatory indicators; | — |
Countries
China
Contacts
Public ContactXiaotao Xu
Shanghai Sixth People’s Hospital
Outcome results
None listed