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A prospective, multicenter, randomized controlled study comparing the efficacy of early and late retroperitoneal drainage in the treatment of severe acute pancreatitis

A prospective, multicenter, randomized controlled study comparing the efficacy of early and late retroperitoneal drainage in the treatment of severe acute pancreatitis

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300076967
Enrollment
Unknown
Registered
2023-10-25
Start date
2023-11-01
Completion date
Unknown
Last updated
2023-10-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute severe pancreatitis

Interventions

Group A:Posterior peritoneal puncture with ultrasound intervention was performed within 7 days of onset.
Group B:4 weeks after the onset of the disease, retroperitoneal puncture and catheter drainage were performed under ultrasound intervention.

Sponsors

Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 85 Years

Inclusion criteria

Inclusion criteria: Guidelines for the Diagnosis and Treatment of Acute Pancreatitis" and do not undergo surgical drainage or other drainage methods before admission. 2) According to Balthazar CT grade D, abdominal ultrasonography showed that the widest parts of peripancreatic, prerenal space, hepatorenal recess, paracolic groove, etc. were more than or equal to 1cm. 3) Meet the ethical requirements, patients voluntarily take the test and sign the informed consent. 4) Patients with high degree of cooperation and compliance; 5) Complete clinical data. 6), age 18-85 years old, male and female.

Exclusion criteria

Exclusion criteria: 1) Patients with organic diseases of heart, liver, kidney, lung and other important organs before the onset of pancreatitis; 2), traumatic pancreatitis; 3) pancreatitis secondary to endoscopic retrograde cholangiopancreatography or intra-abdominal surgery; 4), 1 week after the onset of the hospital admission or before admission has been surgical drainage or other drainage. 5) Patients with abnormal coagulation function that cannot be reversed; 6) Patients with tumor; 7) Restlessness, unable to cooperate with puncture treatment; 8) Patients with other infectious diseases within the past 1 month; 9), suffering from immune diseases. 10), pregnant and lactating women and those planning to become pregnant in the near future.

Design outcomes

Primary

MeasureTime frame
Success rate of retroperitoneal catheterization;Clinical response rate;

Secondary

MeasureTime frame
Complication rate and time of improvement;Adverse event rate;Total length of stay ;Surgical intervention rate;ICU admission rate;Total hospital expenses;

Countries

China

Contacts

Public ContactXiaofeng Zhang

Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine

zxf837@tom.com+86 137 5825 0208

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026