Duchenne muscular dystrophy
Conditions
Interventions
Gold Standard:Cardiac magnetic resonance, CMR
Index test:Cardiac ultrasonic strain
Sponsors
Children's Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
3 Years to 15 Years
Inclusion criteria
Inclusion criteria: Children aged from 3 to 15 years old, diagnosed as DMD by genetic examination or muscle biopsy, can walk continuously, and have 3D-STE and CMR at the same time. Control group: Healthy children undergoing physical examination, without underlying diseases such as heart and kidney that cause heart function damage.
Exclusion criteria
Exclusion criteria: Children with EF<55% or FS<28%, autism, mental retardation, sensitivity to contrast media and claustrophobia on MRI were excluded. There are no other heart diseases, connective tissue diseases, malignant tumors, severe liver, lung and kidney diseases, blood system diseases, various bacterial and viral infections, severe arrhythmia, uremia, hyperthyroidism, and major traumatic surgery history within six months, which lead to cardiac function damage. Those with limited body position and unclear endocardium.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ultrasonic strain;CMR;Accuracy;Sensitivity;Specificity; | — |
Secondary
| Measure | Time frame |
|---|---|
| gal-3;LVEF;ST2;Serological detection indicators; | — |
Countries
China
Contacts
Public ContactYang Chunjiang
Children's Hospital of Chongqing Medical University
Outcome results
None listed