Postoperative sleep disturbance
Conditions
Interventions
remazolam group:Remazolam 0.2 to 0.3 mg/kg was used for anesthesia induction and remazolam 1.0 to 3.0 mg/kg/h for anesthesia maintenance.
propofol group:Propofol (2-4 mg/kg) was used for anesthesia induction and propofol (4-12 mg/kg/h) was used for anesthesia maintenance.
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 89 Years
Inclusion criteria
Inclusion criteria: (1) Age = 60 years old, <90 years old; (2) ASA grade I-III; (3) Patients undergoing elective major abdominal surgery (total/partial gastrectomy, hepatectomy, splenectomy, pancreaticoduodenectomy, or abdominal surgery with a duration greater than 2 hours); (4) The expected end time of the surgery is before 20:00.
Exclusion criteria
Exclusion criteria: (1) Emergency surgery; (2) High risk patients with obstructive sleep apnea (STOP-Bang questionnaire score of 3 or above); (3) Severe cardiac insufficiency (preoperative LVEF<30% or NYHA grade IV); (4) Severe liver dysfunction (Child Pugh C grade); (5) Severe renal dysfunction (receiving dialysis before surgery); (6) Transfer to intensive care unit after surgery; (7) Allergies to research drugs; (8) Preoperative inability to communicate and cooperate with research due to severe dementia or language disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total duration of sleep on the first night after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep efficiency, number of wakefulness and fragmentation index on the first night after surgery;Total sleep duration, sleep efficiency, number of wakes and fragmentation index on the second and third nights after surgery;Subjective sleep quality score from the first night of surgery to the third night after surgery;Cognitive function score on the fifth day after surgery or on the day of discharge;Sleep quality score at 30 days after surgery; | — |
Countries
China
Contacts
Public ContactDongliang Mu
Peking University First Hospital
Outcome results
None listed