Acne
Conditions
Interventions
Experimental group:Azelaic acid gel
Control group:Azelaic acid free matrix
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1) The facial features of patients with mild to moderate acne diagnosed according to the Chinese acne treatment guidelines (2019 version) are as follows: ? 20-50 inflammatory skin lesions (papules, pustules); ? 30-100 non-inflammatory skin lesions (open and closed acne); ? No more than 2 facial nodules; IGA score is mild (2 points) or moderate (3 points); 2) Age 18 to 60; 3) The patient voluntarily participated in the clinical study and signed the written informed consent. And during the whole study period, we should observe the lifestyle precautions: we are willing to use only the cleanser and moisturizer without any drugs provided in this study, and do not use other acne treatment drugs; Do not use foundation make-up, isolation, makeup and other cosmetics; Avoid strenuous exercise within 72 hours before the planned study visit.
Exclusion criteria
Exclusion criteria: 1) Other skin diseases on the face, such as chloasma, freckles and seborrheic dermatitis, may affect the judgment of the test results; 2) People who are allergic to the test product or have high sensitivity constitution; 3) Pregnant, expectant pregnant or lactating patients; 4) The laboratory examination results of liver function and kidney function were judged by doctors as clinically significant abnormalities; 5) Secondary acne patients, such as occupational acne and acne caused by corticosteroids; 6) Patients who take oral antibiotics, glucocorticoids, spironolactones and other anti-androgens and other acne drugs within 4 weeks before the test; Or patients who have used salicylic acid and fruit acid or physical therapy for acne within 2 weeks; 7) Those who took retinoic acid drugs orally within 2 months before the test (6 months for retinoic acid drugs); 8) Two months before the trial, there were facial plastic surgery, grinding, laser, injection therapy and other treatments; 9) Patients with immune deficiency diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| (Acne, papules, pustules, post-inflammatory erythema, post-inflammatory pigmentation) Lesion improvement rate;Acne investigator’s global assessment ;Subjective score of post-inflammatory erythema;Subjective score of post-inflammatory pigmentation;Satisfaction rating;Dermatological quality of life assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Noninvasive skin physiological index detection (Skin water content, transdermal water loss rate, sebum, Lab, black and red pigment); | — |
Countries
China
Contacts
Public ContactXian Jiang
West China Hospital, Sichuan University
Outcome results
None listed