Cervical cancer
Conditions
Interventions
Saline group(Group N):Single intravenous injection of 10ml of saline was given 10min before skin cutting
Eesketamine 0.1 mg / kg group(Group A):Single intravenous injection of esketamine 0.1 mg / kg (diluted to 10ml) 10min before skin cutting
Eesketamine 0.2 mg / kg group(Group B):Single intravenous injection of esketamine 0.2 mg / kg (diluted to 10ml) 10min before skin cutting
Eesketamine 0.4 mg / kg group(Group C):Single intravenous injection of esketamine 0.4 mg / kg (diluted to 10ml) 10min before skin cutting
Sponsors
Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
Female
Age
30 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age: 30~65 years old; 2. ASA grades I to II; 3. Cervical cancer stage III and below; 4.BMI 18~28 kg/m²; 5. Be able to complete the questionnaire independently and voluntarily sign the informed consent form to participate in this trial study.
Exclusion criteria
Exclusion criteria: 1.Severe cardiovascular and cerebrovascular diseases, kidney and liver diseases, or systemic inflammatory diseases; 2. Patients with hyperthyroidism and at risk of increased intracranial pressure; 3. Undercontrolled or untreated hypertension (arterial hypertension, resting systolic / diastolic blood pressure over 180 / 100mmHg); 4.The preoperative SDS score was greater than 53; patients with preoperative sleep disorders (Pittsburgh Scale); 5.Those with mental dysfunction before surgery, and those taking psychotropic drugs before surgery; 6.People with a history of psychotropic drugs, opioids, and alcohol dependence; 7.Allto the drug used in this trial; 8.Participate in other relevant clinical trials and refuse to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prevalence of depression within 7 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Self-rating Scale (SDS) at 1d, 3d, 5d and 7d;Recovery quality scale score at 1d, 3d, 5d and 7d (QoR-15);Sleep quality score on the 1d, 3d, 5d and 7d after operation;Postoperative drug withdrawal-extubation time;In-out PACU time;Time of first rescue analgesia after operation;The amount of remedial analgesic drugs at 1d, 3d, 5d and 7d;Length of postoperative hospitalization;Intraoperative remifentanil dosage;Intraoperative propofol dosage;Intraoperative mean arterial pressure; | — |
Countries
China
Contacts
Public ContactYan Ming
Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed