Depression
Conditions
Interventions
Experimental group:Comprehensive nutrient+ SSRI
Control group:Starch+ SSRI
Sponsors
Beijing AnDing Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: A. Out-patient aged 18-65 years (including 18 and 65 years), regardless of gender; B. Meet the Diagnostic criteria for major depressive disorder (MINI diagnosis) of the American Diagnostic and Statistical Manual of Mental Disorders IV (DSM-IV), first episode or relapse, without psychotic symptoms; C. This attack has not been systematically treated with antidepressants or the cumulative use of antidepressants in the last 14 days has not exceeded 7 days; D. The patient plans to be treated with a single SSRI antidepressant; E. During screening, the total score of QIDS-SR16 =11, the total score of HAMD-17 =14 and the FSS score greater than or equal to 36; F. Primary school education or above, able to understand the content of the scale; G. Informed consent signed by the patient.
Exclusion criteria
Exclusion criteria: A. Previous well-defined episodes of mania or hypomania; B. Previously diagnosed patients with bipolar disorder, schizophrenia, schizoaffective disorder and mental disorders associated with other diseases; C. Patients with a history of alcohol dependence and acute intoxication; D. Pregnant or lactating female patients; E. Currently, researchers with serious physical diseases do not consider it suitable to be included in this study; F. For patients considered by the researchers to be currently at serious risk of suicide, the HAMD-17 suicide risk entry was greater than or equal to 3 points
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Subtraction value of FSS scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Subtraction value of HAMD-17 scale;Study endpoint HAMD-17 reduction rate and remission rate;Study endpoint QIDS-16 reduction rate and remission rate;Subtraction value of QIDS-16 scale;Subtraction value of PSQI scale;Subtraction value of SDS scale;Subtraction value of Q-LES-Q-SF scale;Changes of inflammatory factors, intestinal microbes and other related indicators; | — |
Countries
China
Contacts
Public ContactRuinan Li
Beijing AnDing Hospital, Capital Medical University
Outcome results
None listed