Stroke
Conditions
Sponsors
The Second Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) age =18 years old; 2) stroke onset within 24 hours; 3) an NIHSS score > 5 or a disabling NIHSS score between 3 and 5 at the time of presentation (e.g., strabismus, aphasia, loss of hand function), as determined by the treating physician according to the patient's living conditions; 4) Distal vessel occlusion stroke confirmed by CTA/MRA (MCA: Distal M2, M3, M4; ACA: A1, A2, A3; PCA: P1, P2, P3) and were responsible for the signs and symptoms of acute ischemic stroke. 5) the patient or family signed written informed consent.
Exclusion criteria
Exclusion criteria: 1) intracranial hemorrhage confirmed by imaging; 2) mRS Score =2 before onset; 3) pregnant or lactating women; 4) known allergies to iodine, heparin, anesthesia, or other clear contraindications to endovascular therapy (EVT); 5) The presence of seizures at stroke onset or before treatment and inaccurate NIHSS baseline score; 6) systolic blood pressure > 220mmHg or diastolic blood pressure > 120mmHg, which could not be controlled with antihypertensive drugs; 7) genetic or acquired bleeding constitution, anticoagulant factor deficiency; Or had oral anticoagulants and INR> 3. 8) Blood glucose 22.2mmol/L (400mg/dl), platelet 220µmol/L (2.5mg/dl)); 10) suspected aortic dissection, 11) life expectancy due to advanced stage of any disease < 6 months; 12) anticipated inability to complete follow-up; 13) brain tumors with mass effect (except small meningiomas) or a significant mass effect with midline shift on imaging; 14) are participating in other clinical research; 15) Other circumstances that the investigator believes would pose a significant risk to the subject if they participated in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The rate of 90-day modified RANKIN scale (mRS) score 0-1 (%);mortality at 90 days;Incidence of symptomatic intracranial hemorrhage within 48 hours; | — |
Secondary
| Measure | Time frame |
|---|---|
| Shift in the distribution of mRS scores at 90 days;Proportion of patients with functional independence (mRS score 0 to 2) at 90 days; | — |
Countries
China
Contacts
Public ContactYangmei Chen
The Second Affiliated Hospital of Chongqing Medical University
Outcome results
None listed