postoperative pulmonary complications
Conditions
Interventions
control group:The ventilation mode was adjusted to volume-controlled ventilation (VCV), and PEEP was constant at 5cmH2O
experiment group:The ventilation mode was adjusted to volumecontrolled ventilation (VCV) mode. PEEP was gradually decreased from 14 cmH2O to 2cmH2O, and each titration level was maintained for 6 respi
Sponsors
The affiliated hospital of Southewest Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: Select patients who underwent video assisted thoracoscopic surgery (VATS) lobectomy for lung cancer in our hospital. (1) Patients who are aware of and agree to participate in the clinical observation; (2) Age greater than 60 but less than 80; (3) ASA classification<Level III; (4) No tumor metastasis was found before surgery, and no relevant surgery or chemotherapy was received; (5) There were no significant abnormalities in cardiopulmonary function before surgery, and liver and kidney function were basically normal.
Exclusion criteria
Exclusion criteria: (1) Emergency surgery; (2) Preoperative complications include acute lung injury, pulmonary bullae, severe bronchiectasis, and uncontrolled asthma, Silicosis, pleural effusion, empyema, pleural or chest wall disease, and forced expiratory volume (FEV1) less than 60% in 1 second after inhalation, as well as acute respiratory distress syndrome or respiratory failure three months before surgery and a history of previous lung surgery; (3) Critically ill patients, including liver dysfunction (liver failure or Child Pugh score of B or C); Chronic renal failure (glomerular filtration rate2); (4) Patients with contraindications for nerve block (severe coagulation dysfunction, spinal deformities, systemic or local infections); (5) Difficult airway or intubation; (6) Neuropsychiatric disorders, elderly dementia, psychological disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative pulmonary complications; | — |
Secondary
| Measure | Time frame |
|---|---|
| End-inspiratory lung volume on the ventilated side;hospital stay;MP distribution during one-lung ventilation;Expression levels of inflammatory factors related to lung injury; | — |
Countries
China
Contacts
Public ContactYingying Zhang
The affiliated hospital of Southewest Medical University
Outcome results
None listed