Stroke
Conditions
Interventions
arterial thrombolysis group:NA
Sponsors
The Second Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1) age =18 years old; 2) the time from onset to treatment was within 24 hours; 3) anterior or posterior circulation large vessel occlusive stroke confirmed by CTA/MRA and the vessel responsible for signs and symptoms of acute ischemic stroke; 4) Alberta Stroke Program Early Diagnosis (ASPECTS) score of NCCT =6; 5) eTICI at least 2b after endovascular treatment; 6) Patients or their family members provided written informed consent.
Exclusion criteria
Exclusion criteria: 1) Intracranial hemorrhage confirmed by computed tomography (CT) or magnetic resonance imaging (MRI); 2) receiving intravenous thrombolytic therapy; 3) mRS Score =2 before onset; 4) Intraoperative DSA showed vascular perforation, dissection, and contrast extravasation; 5) pregnant or lactating women; 6) allergy to contrast media; 7) participating in other clinical research; 8) systolic blood pressure > 185mmHg or diastolic blood pressure > 110mmHg, and could not be controlled by oral antihypertensive drugs; 9) genetic or acquired bleeding constitution, anticoagulant factor deficiency; Or have oral anticoagulants and INR > 1.7; 10) Blood glucose 22.2mmol/L (400mg/dl), platelet 220µmol/L (2.5mg/dl)); 13) life expectancy due to advanced stage of any disease 3.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The rate of 90-day modified RANKIN scale (mRS) score 0-1 (%);mortality at 90 days;Incidence of symptomatic intracranial hemorrhage within 48 hours; | — |
Secondary
| Measure | Time frame |
|---|---|
| Shift in the distribution of mRS scores at 90 days;Proportion of patients with functional independence (mRS score 0 to 2) at 90 days; | — |
Countries
China
Contacts
Public ContactYangmei Chen
The Second Affiliated Hospital of Chongqing Medical University
Outcome results
None listed