Chronic kidney disease
Conditions
Interventions
Dietary fibre intervention group:Patients were randomly assigned to the intervention group and supplemented with 15 g of soluble fibre per day for 30 days.
Placebo group :Patients were randomly assigned to the placebo group and supplemented with 15 grams of starch per day for 30 days.
Sponsors
Shanghai Fifth People’s Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients with confirmed CKD who meet the diagnostic and staging criteria for CKD; 2. Age 18~70 years old; 3. Han nationality; 4. Glomerular filtration rate =89mL/min/1.73 m2; 5. No diabetes mellitus before screening; 6. No use of antibiotics in the past 1 month; 7. Those who did not drink yoghurt and probiotics during the voluntary trial; 8. Informed consent to participate in this study.
Exclusion criteria
Exclusion criteria: 1. Comorbidities of severe cardiovascular and metabolic diseases; 2. Pregnant or breastfeeding women; 3. Participated in other clinical trials in the past 3 months or have taken antibiotics within 1 month; 4. Those who drank yoghurt or probiotics within 2 days before the start of the trial; 5. Unwilling participants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Trimethylamine N-oxide;Gut microbiota; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood biochemical indicators;Chronic inflammatory indicators; | — |
Countries
China
Contacts
Public ContactShao Chunhai
Shanghai Fifth People’s Hospital, Fudan University
Outcome results
None listed