Chronic kidney disease
Conditions
Interventions
Case series:None
Sponsors
Huai'an Hospital Affiliated to Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 59 Years
Inclusion criteria
Inclusion criteria: (1)18 years old< age < 59 years old, regardless of gender or race (2)Meets diagnostic criteria for CKD in the US Quality of Prognosis (KDOQI) guidelines (3)Patients were voluntarily enrolled in this study and signed informed consent
Exclusion criteria
Exclusion criteria: (1) Patients with idiopathic and secondary osteoporosis; (2) Patients who may experience secondary bone loss (metabolic, disuse, and certain medications, malnutrition, etc.); (3) Suffering from low bone mass diseases such as bone tumors or Paget's disease (deforming osteoarthritis) or osteogenesis imperfecta; (4) People with endocrine diseases such as diabetes, hyperthyroidism, hyperparathyroidism, etc; (5)Viral infection (including hepatitis B, hepatitis C, and HIV) or recent episode of infection (< 3 months) (6)Immunosuppressive therapy (7)Abnormal liver function (8)Patients with diseases of the blood system (9)Individuals receiving drugs that have an effect on mitochondrial metabolism,Including antivirals,Muscle relaxants,Antipsychotics,Oral steroid preparations,Calcineurin inhibitors,Antiepileptic drugs,Coenzyme Q-10,Nicotinamide riboside or high-dose antioxidant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| T cell mitochondrial function;Bone mineral density; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum B-ALP and TRACP-5b; | — |
Countries
China
Contacts
Public ContactZhengdong Hui
Huai'an Hospital Affiliated to Xuzhou Medical University
Outcome results
None listed