rheumatoid arthritis
Conditions
Interventions
Sponsors
Jiangsu Provincial Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1 Patients who met the diagnostic criteria for RA in rheumatoid arthritis 2. Patients with acute onset within 2 weeks who meet the criteria for RA activity 3. Patients who meet the criteria of RA dampness and heat toxicity syndrome 4. Age is 18-60 years old, male or female 5. Patients enrolled in this study should have previously undiagnosed rheumatoid arthritis and have not received relevant antirheumatic drugs within 3 months prior to disease onset 6. All patients and their families were aware of the study purpose, study method and the risks of participating in the study, volunteered to participate in the study,signed relevant informed consent, and were approved by the Ethics Committee of the Affiliated Hospital of Nanjing University of Traditional Chinese Medicine
Exclusion criteria
Exclusion criteria: 1. Patients with seronegative rheumatic immune diseases and other rheumatic immune diseases such as spinal arthropathy, dermatomyositis, systemic lupus erythematosus, gouty arthritis, Sjogren's syndrome, psoriatic arthritis and scleroderma 2. Patients with severe extraarticular manifestations of rheumatoid arthritis during the onset of the disease 3. Patients with acute or chronic infectious diseases, especially those with septic arthritis 4. Patients with active TB or suspected TB 5. Patients allergic to methotrexate drugs 6. Patients allergic or intolerant to Chinese medicine decoction 7. Pregnant or lactating women who have birth planning within 3 months of the trial or the end of the trial 8. Patients with severe cardiovascular and cerebrovascular diseases such as hypertension, coronary heart disease, cerebral infarction and congestive heart failure; liver and kidney insufficiency andgastrointestinal diseases, especially gastrointestinal ulcer and hematopoietic diseases; patients with malignant tumors 9. Patients with chickenpox 10. Patients with mental system diseases, cognitive dysfunction, consciousness disorders, and inability to communicate effectively 11. Patients with congenital joint deformity, previous fracture trauma of large joint, joint replacement and other surgical treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| metabonomics ;Disease efficacy evaluation;DAS28 rating;Quantitative classification of traditional Chinese medicine syndromes; | — |
Secondary
| Measure | Time frame |
|---|---|
| Rheumatoid factor;anti-ring citrullinine antibody;blood sedimentation;C reactive protein ; | — |
Countries
China
Contacts
Public ContactLU LU
Jiangsu Provincial Hospital of Traditional Chinese Medicine
Outcome results
None listed