Lupus nephritis
Conditions
Interventions
Sponsors
Zhangzhou Municipal Hospital of Fujian Province
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) All SLE patients was diagnosed according to the Systemic Lupus International Collaborating Clinics (SLICC) and American College of Rheumatology (ACR) criteria. LN is diagnosed in patients with SLE when one of the following clinical and laboratory abnormalities occurs: a, proteinuria persists > 0.5 g/24 hours, or urine protein+++ or urine protein/creatinine ratio > 500 mg/g (50 mg/mmol); b, Cell casts include red blood cell casts, hemoglobin casts, granular casts, tubular casts or mixed casts; c, Active urine sediment (excluding urinary tract infection, urine leukocytes >5/HPF, urine red blood cells >5/HPF), or red blood cell casts, or white blood cell casts. (2) Renal biopsy pathology showing immune complex-mediated glomerulonephritis further confirms the diagnosis of LN. (3) Patient's age= 18 years old (adult).
Exclusion criteria
Exclusion criteria: (1) Patients with a history of treatment with biological agents; (2) Serious organic lesions of important organs such as liver, spleen and lungs; (3) Those with primary diseases of the hematopoietic system; (4) Patients with rheumatoid arthritis, viral hepatitis and other immune system diseases; (5) Female patients during lactation or pregnancy; (6) Patients who are allergic to the drug telitacicept.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SRI-4 response rate ; | — |
Secondary
| Measure | Time frame |
|---|---|
| 24h proteinuria ;The negative rate of urinary occult blood;Oral glucocorticoids reduction;Immunoglobulin;Complement;The negative rate of dsDNA; | — |
Countries
China
Contacts
Public ContactXiao-Lu Huang
Zhangzhou Municipal Hospital of Fujian Province
Outcome results
None listed