Aortic stenosis
Conditions
Interventions
Experimental group:Maintain permissive mild hypercapnia (PaCO2: 45-55mmHg)
Control group:Conventional treatment (PaCO2: 35-45mmHg)
Sponsors
Fujian Provincial Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1)Patients with severe aortic stenosis undergoing elective femoral artery TAVR surgery under general anesthesia; (2)Patients voluntarily participate and sign informed consent forms.
Exclusion criteria
Exclusion criteria: (1) History of craniocerebral trauma and stroke; (2) Imaging findings showed significant intracranial vascular stenosis; (3) Preoperative ultrasound examination of carotid artery stenosis > 50%; (4) Severe pulmonary hypertension (mean pulmonary pressure > 45mmHg); (5) Chronic obstructive pulmonary disease; (6) Mental disorders, neurodegenerative diseases, or the use of psychotropic drugs; (7) Preoperative (MMSE) score =23; (8) Inability to perform neurocognitive tests; (9) The clinician considers it inappropriate to participate in the trial or participate in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cognitive function;Cerebral oxygen saturation;Cerebral apoplexy incidence rate;Myocardial infarction incidence rate;Death;Pulmonary infection;Acute kidney injury incidence rate;Arrhythmology;Postoperative hospital stay;Other postoperative complications and adverse events;Postoperative routine detection indicators; | — |
Countries
China
Contacts
Public ContactLihua Lei
Fujian Provincial Hospital
Outcome results
None listed