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Effect of pretreatment with different concentrations of lidocaine on epidural related maternal fever

Effect of ropivacaine on epidural related maternal fever and its effect on inflammatory pathways in placental trophoblast cells

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300076779
Enrollment
Unknown
Registered
2023-10-18
Start date
2023-11-01
Completion date
Unknown
Last updated
2023-10-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

epidural related maternal fever

Interventions

Group A:0.25% lidocaine pretreatment
Group B:0.5% lidocaine pretreatment
Group C:0.75% lidocaine pretreatment
Group D:1% lidocaine pretreatment

Sponsors

Shanghai Jiading District Maternal and Child Health Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 35 Years

Inclusion criteria

Inclusion criteria: 1) No fever (<37.5?) before delivery and no history of vaginitis or other diseases; 2) single fetus, full term (37~41 weeks of pregnancy), cephalic presentation; 3) Obstetrician's assessment that vaginal delivery is possible; 4) willing to receive epidural analgesia and agree to participate in this study;

Exclusion criteria

Exclusion criteria: 1) Contraindications to intrathecal block in combination with abnormalities in coagulation, platelet quantity/quality, etc. 2) Combination of hypertension, diabetes mellitus, hypothyroidism or hyperthyroidism and other diseases 3)Combination of genitourinary infection, upper respiratory tract infection, hepatitis, AIDS and other diseases; 4) Accidental dural puncture, catheter displacement during analgesia, poor analgesic effect of re-puncture, etc; 5) Chorioamnionitis confirmed by pathologic examination; 6) Pregnant women undergoing hormone replacement therapy.

Design outcomes

Primary

MeasureTime frame
body temprature ;inflammatory factors ;

Secondary

MeasureTime frame
Labor duration;Pain VAS score ;

Countries

China

Contacts

Public ContactLuo Wei

Shanghai Jiading District Maternal and Child Health Hospital

13601601923@163.com+86 136 0160 1923

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026